Yes, for most people: melatonin and Zoloft (sertraline) have no known direct interaction.
Both can cause drowsiness, so together they may make you sleepier than you expect. Skip alcohol and do not drive until you know how the combination affects you. Trouble sleeping is also a known side effect of sertraline, particularly early in treatment, so mention it to your prescriber rather than only covering it with a supplement. Short-term melatonin use appears safe for most adults, according to the National Center for Complementary and Integrative Health, but melatonin is sold as a dietary supplement, which means less strict quality control and possible interactions with other medicines. A typical starting dose is 0.5 to 3 mg taken 30 to 60 minutes before bed.
Can I take melatonin with Zoloft? What to do
Common questions
Can I take melatonin with Zoloft?
For most people, yes: there is no known direct interaction between melatonin and sertraline (Zoloft), and many people on Zoloft use melatonin for sleep. Two things are worth knowing. First, both can cause drowsiness, so the combination can make you sleepier than either alone; avoid driving or alcohol until you know how you respond. Second, trouble sleeping is itself a common side effect of sertraline, especially in the first few weeks, so it is worth telling your prescriber rather than only masking it. Short-term melatonin use appears safe for most people, but it is a dietary supplement, so quality varies by brand and it can interact with some medicines. A low dose, 0.5 to 3 mg about an hour before bed, is the usual starting point. If you take other sedating medicines, are pregnant, or your insomnia is new or getting worse on Zoloft, check with your prescriber first.