Usually yes, but water is the better choice, and two juice situations are real.
The first: fruit juices can block absorption of fexofenadine (Allegra). MedlinePlus instructs you to take fexofenadine with water and not with orange, grapefruit, or apple juice. The second: grapefruit juice. The FDA warns that grapefruit juice can let some medicines, including certain statins, blood pressure medicines, and anti-anxiety drugs, build up to unsafe levels in your blood. Grapefruit is not the same as orange, but labels that warn about one juice deserve respect for all of them. Very acidic drinks can also aggravate a stomach already sore from NSAIDs, and extremely hot or acidic drinks can soften some capsules early.
Can I take pills with orange juice? What to do
Common questions
Can I take pills with orange juice?
For most medicines, orange juice is fine, with two important exceptions. First, fruit juices, including orange, grapefruit, and apple juice, block absorption of the allergy medicine fexofenadine (Allegra); MedlinePlus says plainly to take it with water, not fruit juice. Second, grapefruit juice is in a league of its own: the FDA warns it can raise blood levels of dozens of medicines, including some statins, blood pressure drugs, and anti-anxiety medicines, to dangerous levels. Regular orange juice does not have that effect, but if your medicine label warns about grapefruit, treat all juice questions seriously and use water. Acidic juice can also bother a stomach already irritated by medicines like ibuprofen or aspirin, and a big glass of orange juice is acidic enough to slightly change how some drugs dissolve. The boring answer is the right one: water with pills, juice at another time.