Can you drink alcohol while taking Amoxapine?
Last updated September 7, 2026.
**No, you should avoid alcohol while taking amoxapine.** Alcohol increases amoxapine's sedative effects and can make drowsiness, slowed breathing, and poor coordination worse. Alcohol also raises seizure risk and can reduce antidepressant benefit. Combining alcohol with other sedatives or opioids adds danger. Talk with your prescriber before drinking and do not drive or operate machinery after drinking while on this medicine.
What to do
- **Avoid alcohol:** Do not drink while you are taking amoxapine.
- **Check other drugs:** Tell your clinician about sedatives, opioids, or sleeping pills you use.
- **Do not drive:** Avoid driving or operating machinery until you know how you react.
- **Discuss history:** Notify your prescriber if you have seizures or a history of heavy drinking.
- **Seek help:** Call your clinic for severe drowsiness, breathing trouble, or any seizure.
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