Can you drink alcohol while taking Aspirin and Omeprazole?
Last updated September 7, 2026.
**Avoiding alcohol is the safest choice while you take aspirin and omeprazole.** Alcohol can increase stomach irritation and bleeding risk with aspirin and worsen reflux symptoms. Omeprazole reduces stomach acid and helps prevent ulcers, but it does not eliminate aspirin's bleeding risk. Whether an occasional drink is reasonable depends on your aspirin dose, drinking habits, ulcer history, and other medicines. Ask your clinician about your situation, especially if you take blood thinners or drink three or more alcoholic drinks daily. Choose alcohol-free drinks and keep taking your medicines as prescribed.
What to do
- **Choose alcohol-free drinks:** Avoid alcohol to reduce stomach irritation and added bleeding risk.
- **Review your risk:** Tell your clinician your aspirin dose, drinking habits, and any history of ulcers or bleeding.
- **Check other medicines:** Ask your pharmacist before adding ibuprofen or naproxen because they can increase bleeding risk with aspirin.
- **Follow your prescription:** Do not skip prescribed aspirin or take extra omeprazole to make drinking safer.
- **Get emergency care:** Seek emergency care if you vomit blood or material resembling coffee grounds, or have black, tarry stools.
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