Can you take Afamitresgene Autoleucel Injection while pregnant?
Last updated September 7, 2026.
**No. Afamitresgene autoleucel injection (Tecelra) is not given during pregnancy, and your care team checks a pregnancy test before treatment starts.** This is a one-time infusion of your own genetically modified T cells, used for advanced synovial sarcoma in adults who are HLA-A*02 positive with a MAGE-A4 positive tumor. It has not been studied in pregnant patients, so there is no safety data to rely on. The bigger known risk is the step before the infusion: you receive lymphodepleting chemotherapy with fludarabine and cyclophosphamide, and both can harm a developing fetus. If you can become pregnant, expect a pregnancy test before lymphodepleting chemotherapy and a conversation about reliable contraception. Tell your oncology team right away if you are pregnant, think you might be, or become pregnant at any point during treatment or follow-up.
What to do
- Confirm pregnancy status first: Expect a pregnancy test before lymphodepleting chemotherapy if you can become pregnant, and ask for the result.
- Speak up early: Tell your oncology team if you are pregnant or might be before any part of the treatment process begins.
- Plan contraception: Ask how long to use reliable birth control before and after treatment, since the chemotherapy drugs have their own timelines.
- Ask about fertility: Raise fertility preservation before lymphodepleting chemotherapy, because options narrow once treatment starts.
- Bring in both teams: If you are already pregnant, ask your oncologist to coordinate with a maternal-fetal medicine specialist.
- Pause on breastfeeding: Ask whether to stop or delay breastfeeding, since it has not been studied with this therapy.
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