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Short answer Pregnancy and cell therapy: what to know Common questions Related questions Sources**No. Afamitresgene autoleucel injection (Tecelra) is not given during pregnancy, and your care team checks a pregnancy test before treatment starts.**
This is a one-time infusion of your own genetically modified T cells, used for advanced synovial sarcoma in adults who are HLA-A*02 positive with a MAGE-A4 positive tumor. It has not been studied in pregnant patients, so there is no safety data to rely on. The bigger known risk is the step before the infusion: you receive lymphodepleting chemotherapy with fludarabine and cyclophosphamide, and both can harm a developing fetus. If you can become pregnant, expect a pregnancy test before lymphodepleting chemotherapy and a conversation about reliable contraception. Tell your oncology team right away if you are pregnant, think you might be, or become pregnant at any point during treatment or follow-up.
Pregnancy and cell therapy: what to know
Common questions
Can you take Afamitresgene Autoleucel Injection while pregnant?
No. Afamitresgene autoleucel (Tecelra) has not been studied in pregnancy, and the treatment course is not considered safe for a fetus. Before the cells are infused, you receive lymphodepleting chemotherapy with fludarabine and cyclophosphamide, drugs known to harm a developing fetus. For that reason, a pregnancy test is done before lymphodepleting chemotherapy in anyone who can become pregnant, and reliable contraception is advised. If you are pregnant and have advanced synovial sarcoma, your oncology team is the right group to weigh treatment timing, alternative therapies, and care for the pregnancy together.