Can you take Aficamten while pregnant?
Last updated September 7, 2026.
**No, aficamten is not recommended during pregnancy, because animal reproduction studies showed it can harm a developing fetus.** There is no established safe dose for use in human pregnancy, so prescribers advise reliable contraception while you take it and for a period after your last dose. If a pregnancy is planned or unexpected, your cardiologist can review a switch to a medicine with a longer track record in pregnancy, such as a beta blocker. Do not stop aficamten on your own, since symptoms and outflow obstruction can come back. Pregnancy with hypertrophic cardiomyopathy is managed best by a cardiologist and an obstetrician working together from early on. Bring a list of every medicine and supplement you take to that first visit.
What to do
- Tell your care team early: Say you are pregnant or planning a pregnancy before your next refill so the plan can change in time.
- Use reliable birth control: Keep using effective contraception while you take aficamten and for the period your prescriber specifies after the last dose.
- Do not stop on your own: Abruptly stopping can bring back chest pain, breathlessness, and fainting, so any change should be supervised.
- Ask about beta blockers: Beta blockers such as metoprolol are commonly used for hypertrophic cardiomyopathy in pregnancy and may be an option for you.
- Build a shared care team: Ask for a cardiologist and obstetrician who coordinate on high risk heart conditions, ideally before you conceive.
- Check breastfeeding separately: Pregnancy and nursing advice differ, so ask your clinician what to do after delivery instead of assuming the same answer.
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