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Short answer Pregnancy and aficamten: what to know Common questions Related questions Sources**No, aficamten is not recommended during pregnancy, because animal reproduction studies showed it can harm a developing fetus.**
There is no established safe dose for use in human pregnancy, so prescribers advise reliable contraception while you take it and for a period after your last dose. If a pregnancy is planned or unexpected, your cardiologist can review a switch to a medicine with a longer track record in pregnancy, such as a beta blocker. Do not stop aficamten on your own, since symptoms and outflow obstruction can come back. Pregnancy with hypertrophic cardiomyopathy is managed best by a cardiologist and an obstetrician working together from early on. Bring a list of every medicine and supplement you take to that first visit.
Pregnancy and aficamten: what to know
Common questions
Can you take Aficamten while pregnant?
Aficamten is a cardiac myosin inhibitor used for obstructive hypertrophic cardiomyopathy, and it is not recommended in pregnancy. Animal studies showed fetal harm, so the labeling calls for effective birth control during treatment and for a period after the last dose. If you are planning a pregnancy or think you may be pregnant, contact your cardiologist promptly rather than stopping the drug yourself, because stopping suddenly can worsen symptoms and obstruction. Many people move to a beta blocker such as metoprolol, which has long been used in pregnancy. A joint cardiology and obstetrics team should guide care through delivery.