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Short answer Pregnancy and aflibercept: what to know Common questions Related questions Sources**Aflibercept injection is generally not recommended during pregnancy, so treatment is usually postponed or another approach is used.**
Aflibercept works by blocking VEGF, a protein a developing fetus needs to build normal blood vessels, and animal studies have shown harm to the fetus. Eye injections use a small dose, but a measurable amount still reaches your bloodstream. The prescribing information advises effective birth control before your first dose, throughout treatment, and for at least 3 months after your last injection. The decision depends on how fast your eye condition is progressing, how much vision is at stake, and whether laser treatment or close monitoring can safely bridge the pregnancy. Bring your eye specialist and your pregnancy care provider into the same conversation so one plan covers both.
Pregnancy and aflibercept: what to know
Common questions
Can you take Aflibercept Injection while pregnant?
Aflibercept is usually avoided during pregnancy. It blocks VEGF, a protein needed for normal blood vessel growth in a developing fetus, and animal studies showed fetal harm. Injections into the eye use a small dose, but some drug still enters your bloodstream. The labeling advises effective contraception before the first dose, during treatment, and for at least 3 months after the last injection. If you are pregnant, trying to conceive, or become pregnant during treatment, tell your eye specialist and your pregnancy care provider promptly. They can compare your risk of vision loss against fetal risk and discuss alternatives such as laser treatment or careful monitoring until after delivery.