Can you take Alpelisib while pregnant?
Last updated September 7, 2026.
**You should avoid alpelisib during pregnancy because it can harm your developing baby.** Animal studies show harm to developing offspring, and human pregnancy data are insufficient to measure the risk. If you are pregnant or think you might be, contact your prescribing specialist promptly to discuss your next dose and treatment options. If you can become pregnant, you need a pregnancy test before starting treatment and effective birth control during treatment and for 1 week after your last dose. Other medicines in your treatment plan may require birth control for longer, so confirm the full timeline with your specialist.
What to do
- **Contact your specialist:** Report a known or suspected pregnancy promptly and ask for instructions about your next dose.
- **Test before treatment:** Arrange a pregnancy test before starting alpelisib if you can become pregnant.
- **Use birth control:** Use effective contraception during treatment and for 1 week after your last dose.
- **Check partner precautions:** If you take alpelisib and your partner can become pregnant, use condoms plus effective birth control during treatment and for 1 week afterward.
- **Review your other medicines:** Ask your specialist whether your full treatment plan requires contraception for longer.
- **Pause breastfeeding:** Do not breastfeed during alpelisib treatment or for 1 week after your last dose.
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