Can you take Anifrolumab-fnia Injection while pregnant?
Last updated September 7, 2026.
**Taking anifrolumab-fnia (Saphnelo) while pregnant requires an individual decision with your lupus specialist because its pregnancy safety is not established.** Human pregnancy data are too limited to determine whether this medicine increases the risk of birth defects or miscarriage. Your baby’s exposure may be greater in the third trimester because antibodies cross the placenta as pregnancy progresses. Your clinician must also consider the pregnancy risks of active lupus when reviewing treatment options. Tell your lupus specialist and pregnancy care clinician if you are pregnant or planning pregnancy, and get advice before changing your treatment.
What to do
- **Plan ahead:** Review your lupus treatment with your specialist before trying to become pregnant.
- **Contact your prescriber:** Report a suspected or confirmed pregnancy promptly so you can discuss your next dose.
- **Review your medicines:** Bring a list of your prescriptions, supplements, and nonprescription medicines to your pregnancy visit.
- **Coordinate your care:** Ask your lupus specialist and pregnancy care clinician to agree on your treatment plan.
- **Ask about the registry:** Discuss joining the pregnancy exposure registry if you received Saphnelo during pregnancy.
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