Can you take Ceftolozane and Tazobactam Injection while pregnant?
Last updated September 7, 2026.
**You can receive ceftolozane and tazobactam injection during pregnancy if your clinician determines that the expected benefit outweighs the potential risks.** Human pregnancy data are insufficient to assess the risks of this specific antibiotic combination, also called Zerbaxa. Experience with other cephalosporin antibiotics is reassuring, but it does not establish this combination's safety. Your clinician considers your infection, available alternatives, allergies, and kidney function when choosing treatment. Tell your prescribing team if you are pregnant or could be pregnant, and discuss any concerns before changing your treatment.
What to do
- **Share your pregnancy status:** Tell your prescribing team if you are pregnant, planning pregnancy, or could be pregnant.
- **Review treatment options:** Ask your clinician why this antibiotic is needed and whether an effective alternative has more pregnancy safety data.
- **Report antibiotic allergies:** Describe any past reactions to penicillins, cephalosporins, or other antibiotics before your infusion.
- **Mention kidney problems:** Tell your clinician about kidney disease because your dose may need adjustment.
- **Follow your treatment plan:** Contact your prescriber before skipping doses or stopping treatment.
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