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Can you take Ceftolozane and Tazobactam Injection while pregnant?

Updated Sep 7, 20261 min readAnswer
On this pageShort answer Pregnancy and this antibiotic combination: what to know Common questions Related questions Sources
Short answer

**You can receive ceftolozane and tazobactam injection during pregnancy if your clinician determines that the expected benefit outweighs the potential risks.**

Human pregnancy data are insufficient to assess the risks of this specific antibiotic combination, also called Zerbaxa. Experience with other cephalosporin antibiotics is reassuring, but it does not establish this combination's safety. Your clinician considers your infection, available alternatives, allergies, and kidney function when choosing treatment. Tell your prescribing team if you are pregnant or could be pregnant, and discuss any concerns before changing your treatment.

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Pregnancy and this antibiotic combination: what to know

1**Share your pregnancy status:**Tell your prescribing team if you are pregnant, planning pregnancy, or could be pregnant.
2**Review treatment options:**Ask your clinician why this antibiotic is needed and whether an effective alternative has more pregnancy safety data.
3**Report antibiotic allergies:**Describe any past reactions to penicillins, cephalosporins, or other antibiotics before your infusion.
4**Mention kidney problems:**Tell your clinician about kidney disease because your dose may need adjustment.
5**Follow your treatment plan:**Contact your prescriber before skipping doses or stopping treatment.

Common questions

Can you take Ceftolozane and Tazobactam Injection while pregnant?

You can receive ceftolozane and tazobactam injection (Zerbaxa) while pregnant when your clinician judges that its expected benefits outweigh potential risks. There are no adequate human pregnancy data to establish this combination's safety. It is given into a vein for certain bacterial infections, including complicated urinary and abdominal infections and certain pneumonias. Tell your prescriber if you are pregnant or could be pregnant, and review your antibiotic allergies and kidney problems. If you become pregnant during treatment, contact your prescriber rather than stopping doses yourself.

About this page. Written and maintained by the Pymander Health team. Last updated September 7, 2026.

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