Can you take Daratumumab Injection while pregnant?
Last updated September 7, 2026.
**No, daratumumab injection is not recommended during pregnancy unless your cancer team decides the benefit to you clearly outweighs the risk to the baby.** Daratumumab is an antibody that crosses the placenta, and antibodies of this type can reduce a baby's immune cells before birth. Because of that, pregnancy is confirmed as negative before treatment starts, and effective birth control is advised during treatment and for 3 months after the last dose. The picture also depends on what daratumumab is combined with, since lenalidomide, thalidomide, and pomalidomide cause serious birth defects and carry their own pregnancy prevention requirements. If you are pregnant, think you may be, or want to conceive later, that is a conversation for your oncologist and an obstetrician together, not a decision to make by skipping infusions. Keep a written list of every drug in your regimen so any clinician you see knows exactly what you are on.
What to do
- Confirm before you start: Expect a pregnancy test before the first dose and agree on a birth control plan with your care team.
- Cover the full window: Use effective contraception during treatment and for 3 months after your last daratumumab dose.
- Check the whole regimen: Ask which other drugs you take with daratumumab, since lenalidomide, thalidomide, and pomalidomide have separate pregnancy rules.
- Report a positive test fast: Call your oncologist the same day if you become pregnant, and keep your appointments while the plan is reviewed.
- Plan fertility early: Raise future pregnancy goals before treatment starts so options can be discussed while there is still time.
- Flag exposure at delivery: Tell the pediatric team about in-utero exposure so newborn immune counts and live vaccine timing can be checked.
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