How long does Alkaptonuria last?
Last updated September 7, 2026.
**Alkaptonuria is an inherited condition that lasts your whole life.** If you have alkaptonuria, it is present from birth, even if you do not notice symptoms until adulthood. A substance called homogentisic acid builds up over time, causing dark urine and eventually affecting cartilage and joints. Your symptoms and how quickly they progress vary, but appropriate medical care generally allows a normal life expectancy. Regular follow-up and a physical therapy plan can help you manage pain and maintain movement.
What to do
- **Get evaluated:** Contact your clinician if your urine turns dark brown or black after standing, since diagnosis requires testing.
- **Plan ongoing care:** Ask your clinician how often you need checks for joint, heart valve, and kidney problems.
- **Support movement:** Ask a physical therapist for exercises suited to your joint symptoms and mobility.
- **Review pain relief:** Discuss persistent pain with your clinician to choose treatment that fits your health history.
- **Get nutrition guidance:** Consult your care team before restricting protein so your diet still meets your nutritional needs.