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How long does Amisulpride Injection take to work?

Updated Sep 7, 20262 min readAnswer
On this pageShort answer What to expect from an amisulpride injection Common questions Related questions Sources
Short answer

**Amisulpride injection works quickly: it goes straight into a vein, and relief from nausea is usually noticeable within about 30 minutes.**

In the US, amisulpride injection is sold as Barhemsys and is used only to prevent or treat nausea and vomiting after surgery. Because it is given intravenously over 1 to 2 minutes, drug levels peak almost immediately rather than building up over days. Timing feels different depending on the situation: a dose given at the start of anesthesia is meant to keep nausea from starting, while a dose given in recovery is judged by how you feel over the next hour. Anesthesia, opioid pain medicine, and motion during transport can all keep nausea going even after the drug is on board. This injection is not the same as oral amisulpride used outside the US as an antipsychotic, which takes weeks to show its full effect.

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What to expect from an amisulpride injection

1Expect minutes, not days:An IV dose acts within about half an hour, so judge it by the end of that first hour.
2Speak up in recovery:Tell your nurse if nausea persists or returns so another antiemetic can be added.
3Know the one-dose limit:Amisulpride injection is given as a single 10 mg dose, and repeat doses are not recommended.
4Share your full drug list:Mention any medicine that affects heart rhythm, since this drug can prolong the QT interval.
5Flag kidney problems:Reduced kidney function changes how long the drug stays in your body, so your team needs to know.
6Do not confuse it with tablets:Oral amisulpride is a different use and a different timeline, and it is not approved in the US.

Common questions

How long does Amisulpride Injection take to work?

Amisulpride injection is the IV antiemetic Barhemsys, used to prevent or treat nausea and vomiting after surgery. It is given into a vein over 1 to 2 minutes, so blood levels peak right away and the anti-nausea effect usually begins within about 30 minutes. For prevention, a 10 mg dose is given around the start of anesthesia. For nausea that has already started, a 10 mg dose is given after surgery, and repeat dosing is not recommended. If you still feel sick an hour after the dose, tell your nurse or anesthesia team, since a drug from a different class often works better than a second dose of the same one.

About this page. Written and maintained by the Pymander Health team. Last updated September 7, 2026.

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