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Short answer Life on degarelix: what to track Common questions Related questions Sources**Degarelix leaves the body slowly: it has an average terminal half-life of about 53 days after a subcutaneous injection, so most people take roughly 8 to 9 months to clear it fully after the last dose.**
The injection forms a small gel depot under the skin of your abdomen that keeps releasing drug for weeks, which is why the tail is so long compared with a pill. How long you were treated, your dose, and reduced kidney or liver function can stretch or shorten that window. Clearance and effect are two different clocks: testosterone stays suppressed the whole time depot levels remain high, and many men need several months after the final injection before testosterone climbs back toward baseline. Your care team tracks this with testosterone and PSA blood tests rather than by measuring the drug itself. Keep injection dates in one place so you and your clinician can line up lab results with your last dose.
Life on degarelix: what to track
Common questions
How long does Degarelix Injection stay in your system?
Degarelix forms a gel depot under the skin and releases slowly, which gives it an average terminal half-life of about 53 days. Using the usual rule of roughly five half-lives, the drug is essentially gone about 8 to 9 months after your last injection. The effects follow a separate schedule: testosterone stays suppressed while depot levels are high, and it commonly takes several months after stopping for testosterone to recover. Your dose, how long you were treated, and kidney or liver problems can shift the timing. If you are stopping treatment, changing therapy, or planning surgery, ask your oncology team when levels should be low enough to matter.