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Is Anacaulase-bcdb topical addictive?

Updated Sep 7, 20261 min readAnswer
On this pageShort answer Anacaulase and dependence: what to know Common questions Related questions Sources
Short answer

**No, anacaulase-bcdb topical is not known to be addictive.**

You receive this medicine, sold as NexoBrid, to remove dead tissue from certain deep burns caused by heat. It contains enzymes from pineapple stems, and your healthcare team applies and removes the gel during a supervised procedure. You also receive separate medicines for pain, so ask your clinician about their individual addiction risks. Share your medication list, allergy history, and any history of substance use problems before treatment.

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Anacaulase and dependence: what to know

1**Ask about pain medicines:**Have your clinician explain which medicines you will receive and their addiction risks.
2**Share your history:**Tell your care team about any past substance use problems before treatment.
3**Review your medicines:**Give your clinician a list of your prescriptions, supplements, and nonprescription medicines.
4**Mention allergies:**Tell your team if you are allergic to pineapple, papaya, bromelain, or papain.
5**Report bleeding risks:**Tell your clinician about bleeding disorders or blood thinner use before the procedure.

Common questions

Is Anacaulase-bcdb topical addictive?

No, anacaulase-bcdb topical (NexoBrid) is not known to cause addiction. It uses enzymes from pineapple stems to dissolve dead tissue from deep burns caused by heat. Your doctor or nurse applies the gel and removes it after 4 hours; it is usually a single treatment. You receive separate pain medicines during the procedure, and their addiction risks depend on which medicines you receive. Ask your clinician to explain your pain treatment plan, especially if you have a history of substance use problems. Tell your team about pineapple or papaya allergies, bleeding disorders, and blood thinners.

About this page. Written and maintained by the Pymander Health team. Last updated September 7, 2026.

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