Is it safe to clean a litter box while pregnant?

Ideally, no: the standard advice is to hand litter-box duty to someone else for nine months, and that advice exists because of toxoplasmosis. The CDC says a first-time Toxoplasma infection during pregnancy, or just before it, can pass to your baby, with consequences that include eye and brain damage. The cat connection is specific: cats shed the parasite in feces after eating infected prey, and crucially, the parasite does not become infectious until one to five days after it is shed, which is why the CDC's own prevention advice centers on changing the litter box daily, removing the feces before they become dangerous. If nobody else can do it, the CDC-aligned routine: scoop daily, wear disposable gloves, wash hands thoroughly with soap and water afterward, and avoid stirring up dust, with a mask as extra caution. The risk calibration helps too: indoor cats that eat only commercial food and do not hunt rarely carry the parasite, so the pampered indoor moggie is low-risk, while the outdoor hunter is the one to be strict about. The other half of prevention travels together: gloves for gardening since soil carries cat feces, and no raw or undercooked meat, which is actually the most common route in many countries. And keep the cat: the advice is managing feces, not rehoming your pet.