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What are the side effects of Abaloparatide Injection?

Updated Sep 6, 20262 min readAnswer
On this pageShort answer Living with abaloparatide: what to watch for Common questions Related questions Sources
Short answer

**Most side effects of abaloparatide (Tymlos) are mild and short lived: dizziness, nausea, headache, a fast or pounding heartbeat, tiredness, and redness or swelling where you inject.**

Which ones you notice depends on your blood pressure, when you inject, and whether you also take calcium and vitamin D. Dizziness and a racing heartbeat usually show up within about four hours of a dose and often ease over the first few months of treatment. Rotating to a different spot on your abdomen each day and letting the pen sit out of the refrigerator before injecting cuts down on stinging and redness. Keep the pen refrigerated until the first use, then store it at room temperature and discard it 30 days after that first injection. Tell your clinician if you have had radiation to your bones, a bone cancer, or high blood calcium, because abaloparatide may not be a good fit.

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Living with abaloparatide: what to watch for

1Dose sitting down:Give the first several injections while seated or lying down, and stand up slowly afterward until you know how it affects you.
2Rotate the site:Inject into a different spot on your lower abdomen each day and skip areas that are tender, bruised, or hard.
3Time it for comfort:If dizziness or nausea bothers you, ask your clinician about injecting at a time of day when you can rest for an hour or two.
4Watch your calcium:Report ongoing constipation, unusual thirst, frequent urination, or muscle weakness, since these can signal calcium building up.
5Handle the pen right:Refrigerate it before first use, then keep it at room temperature and throw it away 30 days after your first injection.
6Plan the full course:Ask your clinician how long you should stay on it and what medicine follows, because bone density gains fade once you stop.

Common questions

What are the side effects of Abaloparatide Injection?

Abaloparatide (Tymlos) is a daily injection under the skin for osteoporosis with high fracture risk. The most common side effects are dizziness, nausea, headache, a pounding or fast heartbeat, tiredness, upper stomach pain, and redness, swelling, or itching at the injection site. Some people feel lightheaded within a few hours of a dose because blood pressure dips on standing, so take the first several doses where you can sit or lie down. It can also raise calcium in your blood and urine, which may cause constipation, thirst, or muscle weakness. Contact your clinician about fainting, repeated vomiting, or new bone pain, and go to urgent care if you have chest pain or trouble breathing.

About this page. Written and maintained by the Pymander Health team. Last updated September 6, 2026.

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