What are the side effects of Acetaminophen Injection?
Last updated September 7, 2026.
**Acetaminophen injection can cause nausea, vomiting, headache, and trouble sleeping, with serious risks including liver injury and allergic or skin reactions.** You receive this medicine through an IV, and your dose depends on your weight and medical needs. Your risk of liver injury increases if you receive too much acetaminophen, including from other medicines you take. Tell your care team about liver disease, alcohol use, and every prescription and nonprescription medicine you use. Ask your nurse or clinician about symptoms that persist, and report any new rash immediately.
What to do
- **Check your medicines:** Ask your pharmacist to check pain, cold, and sleep products for acetaminophen before you take them.
- **Share your history:** Tell your clinician about liver disease and how much alcohol you drink before treatment.
- **Report ongoing symptoms:** Tell your nurse or clinician if nausea, vomiting, headache, or IV discomfort persists or worsens.
- **Report warning signs:** Get immediate medical advice for a new rash, blisters, yellow skin or eyes, or dark urine.
- **Get emergency help:** For trouble breathing or throat swelling, alert medical staff immediately or call 911 if you are outside a medical facility.
- **Act on a possible overdose:** If you think you received or took too much acetaminophen, get medical help immediately even if you feel well.
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