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What are the side effects of Acyclovir Buccal?

Updated Sep 7, 20261 min readAnswer
On this pageShort answer Side effects of acyclovir buccal: what to do Common questions Related questions Sources
Short answer

**Acyclovir buccal can cause headache, gum pain or irritation, and canker sores.**

You use this cold sore medicine as a tablet that sticks to your upper gum and dissolves slowly. Most treatment related side effects in studies were mild or moderate. Your allergy history matters because the tablet contains milk protein. Let it dissolve without chewing or sucking it, and contact your clinician if mouth discomfort is severe or does not go away.

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Side effects of acyclovir buccal: what to do

1**Check allergies:**Tell your prescriber about any allergy to acyclovir, valacyclovir, or milk protein before using the tablet.
2**Let it dissolve:**Keep the tablet on your upper gum without chewing, crushing, or sucking it.
3**Avoid disturbing it:**Avoid chewing gum and touching the tablet while it is attached.
4**Report ongoing symptoms:**Contact your clinician if gum pain, irritation, or canker sores are severe or do not go away.
5**Get emergency help:**Call 911 if you have trouble breathing or swelling of your tongue or throat.

Common questions

What are the side effects of Acyclovir Buccal?

Acyclovir buccal (Sitavig) can cause headache, pain or irritation where the tablet touches your gum, and canker sores. Most treatment related side effects in studies were mild or moderate. Let the tablet dissolve on your upper gum without chewing, crushing, or sucking it. Contact your clinician if you develop severe or persistent mouth discomfort or a new rash. Call 911 for trouble breathing or swelling of your tongue or throat. Do not use it if you are allergic to acyclovir, milk protein, or another tablet ingredient.

About this page. Written and maintained by the Pymander Health team. Last updated September 7, 2026.

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