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Short answer Handling agalsidase beta infusion reactions Common questions Related questions Sources**The most common side effects of agalsidase beta injection are infusion-associated reactions such as chills, fever, feeling hot or cold, headache, nausea, and flushing, which usually start during the infusion or within a few hours after it.**
Agalsidase beta is an enzyme replacement therapy for Fabry disease, given by vein about every two weeks, and reactions are most likely in the first several months of treatment. Serious allergic reactions, including anaphylaxis, have happened, so infusions are given in a setting with trained staff and emergency medicines on hand. Many people are premedicated with an antihistamine, acetaminophen, or a corticosteroid, and slowing the infusion rate often reduces symptoms. Some people develop antibodies to the drug, which can make infusion reactions more likely, so your team may check antibody levels. Keep a simple log of what you feel at each infusion and at what point in the drip it started, since that helps your team adjust the rate or the premedication.
Handling agalsidase beta infusion reactions
Common questions
What are the side effects of Agalsidase beta Injection?
Most side effects show up as infusion-associated reactions: chills, fever, feeling hot or cold, headache, nausea, flushing, tiredness, and itching or rash. Cough, sore throat, stuffy nose, dizziness, tingling in the hands or feet, belly pain, and swelling in the legs are also reported. Serious allergic reactions, including anaphylaxis, can occur, which is why infusions are given where emergency treatment is available. Your care team may premedicate you and slow the infusion rate if reactions happen. Report trouble breathing, chest tightness, hives, throat swelling, or feeling faint right away, and tell your team about milder symptoms before your next dose so the plan can be adjusted.