What are the side effects of Amisulpride Injection?
Last updated September 7, 2026.
**Amisulpride injection, given as a single IV dose in a hospital or surgery center for nausea and vomiting, most often causes chills, a low potassium level on blood tests, pain at the IV site, and a short drop in blood pressure.** Most of these effects are mild and pass within hours, and your care team is watching you while the medicine is working. The main safety point is that amisulpride can lengthen the QT interval, which is a measure of heart rhythm timing, so it matters if you have heart disease, low potassium or magnesium, or take other medicines that affect QT. Tell your anesthesia or surgical team about every prescription, over-the-counter product, and supplement you take before your procedure. Because this is one low dose rather than daily therapy, the muscle stiffness, restlessness, and hormone changes linked to long-term oral antipsychotics are not expected. Call your clinician if you feel faint, notice a racing or irregular heartbeat, or develop a rash after you go home.
What to do
- Share your full medicine list: Before surgery, tell the anesthesia team about every drug and supplement you take, especially ones that affect heart rhythm.
- Flag heart history: Say if you have had a long QT diagnosis, an irregular heartbeat, heart failure, or a family history of sudden cardiac death.
- Mention low potassium or magnesium: Diuretics, vomiting, and diarrhea can drop these levels, and correcting them lowers the rhythm risk.
- Expect short-lived effects: Chills, IV site soreness, and bloating usually settle the same day and rarely need treatment.
- Watch after discharge: Get medical care for fainting, chest pounding, a very fast or irregular pulse, or trouble breathing.
- Ask about kidney dosing: Amisulpride is cleared by the kidneys, so tell your clinician if you have reduced kidney function.
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