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What are the side effects of Amisulpride Injection?

Updated Sep 7, 20262 min readAnswer
On this pageShort answer Living with amisulpride injection: what to watch for Common questions Related questions Sources
Short answer

**Amisulpride injection, given as a single IV dose in a hospital or surgery center for nausea and vomiting, most often causes chills, a low potassium level on blood tests, pain at the IV site, and a short drop in blood pressure.**

Most of these effects are mild and pass within hours, and your care team is watching you while the medicine is working. The main safety point is that amisulpride can lengthen the QT interval, which is a measure of heart rhythm timing, so it matters if you have heart disease, low potassium or magnesium, or take other medicines that affect QT. Tell your anesthesia or surgical team about every prescription, over-the-counter product, and supplement you take before your procedure. Because this is one low dose rather than daily therapy, the muscle stiffness, restlessness, and hormone changes linked to long-term oral antipsychotics are not expected. Call your clinician if you feel faint, notice a racing or irregular heartbeat, or develop a rash after you go home.

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Living with amisulpride injection: what to watch for

1Share your full medicine list:Before surgery, tell the anesthesia team about every drug and supplement you take, especially ones that affect heart rhythm.
2Flag heart history:Say if you have had a long QT diagnosis, an irregular heartbeat, heart failure, or a family history of sudden cardiac death.
3Mention low potassium or magnesium:Diuretics, vomiting, and diarrhea can drop these levels, and correcting them lowers the rhythm risk.
4Expect short-lived effects:Chills, IV site soreness, and bloating usually settle the same day and rarely need treatment.
5Watch after discharge:Get medical care for fainting, chest pounding, a very fast or irregular pulse, or trouble breathing.
6Ask about kidney dosing:Amisulpride is cleared by the kidneys, so tell your clinician if you have reduced kidney function.

Common questions

What are the side effects of Amisulpride Injection?

Amisulpride injection (brand name Barhemsys) is a single low dose given through an IV during or after surgery to prevent or treat nausea and vomiting. The most common effects reported are chills, low potassium on blood tests, pain where the IV sits, low blood pressure during the procedure, and abdominal bloating. It can also lengthen the QT interval, a change in heart rhythm timing, so your care team may check an ECG or potassium level if you have heart disease or take other QT-prolonging medicines. Because it is a single dose, the ongoing effects of daily oral antipsychotics are not expected. Tell your team about fainting, a fast or irregular heartbeat, or a rash.

About this page. Written and maintained by the Pymander Health team. Last updated September 7, 2026.

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