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Short answer Living with amivantamab: what to watch for Common questions Related questions SourcesThe most common side effects of amivantamab-vmjw (Rybrevant) are infusion-related reactions, an acne-like rash, painful skin and nail changes around the fingers and toes, swelling in the face or legs, mouth sores, and fatigue.
Infusion reactions are most likely with the very first dose, which is why the first infusion is split over two days and you get premedications beforehand. Skin effects tend to build over the first few weeks and are usually manageable with moisturizers, antibiotic creams or pills, and sun protection. Less common but more serious effects include lung inflammation (pneumonitis), eye problems such as keratitis, and blood clots, especially when the drug is combined with lazertinib. Your oncology team checks labs, including albumin, and reviews your skin and breathing at each visit. Report new cough, shortness of breath, fever, vision changes, or leg swelling the same day rather than waiting for your next appointment.
Living with amivantamab: what to watch for
Common questions
What are the side effects of Amivantamab-vmjw Injection?
Most people have an infusion-related reaction with the first dose, often within the first hour: chills, shortness of breath, flushing, nausea, or chest discomfort. Your team slows or pauses the infusion and gives medicines before each dose to lower the risk. Skin effects build over the first few weeks: acne-like rash on the face and chest, dry itchy skin, and painful swelling around the nails. Other common effects are swelling in the legs or face, mouth sores, low blood albumin, constipation or diarrhea, eye irritation, and fatigue. Call your cancer team right away for new or worsening cough, shortness of breath, or fever, which can signal lung inflammation.