What are the side effects of Amphotericin B Injection?
Last updated September 8, 2026.
**Common side effects are fever, chills, nausea, infusion reactions, kidney injury, and low potassium or magnesium.** Which effects you get depends on the formulation, dose, and your kidney health. Liposomal or lipid formulations cause fewer kidney problems than the older deoxycholate form. Your team will check blood tests and electrolytes regularly and may give premedication and a slower infusion to reduce reactions. Call your clinician if you have high fever, trouble breathing, fainting, little urine, or severe muscle weakness.
What to do
- **Check labs:** Ask your clinician how often they will check kidney function and electrolytes.
- **Stay hydrated:** Drink fluids as directed and follow any IV fluid orders to protect your kidneys.
- **Report symptoms:** Tell your care team right away about high fever, chest pain, trouble breathing, fainting, or low urine.
- **Ask about premeds:** Premedication such as acetaminophen or antihistamines can reduce infusion reactions.
- **Know the formulation:** Confirm whether you are getting a liposomal or conventional product because risks differ.
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