What are the side effects of Asenapine Transdermal Patch?
Last updated September 7, 2026.
**Asenapine transdermal patches can cause skin irritation, weight gain, sleepiness, dizziness, restlessness, and muscle stiffness or tremor.** Your risk depends on your dose, other medicines, and health conditions. Your blood sugar and cholesterol can rise, so your prescriber should monitor these along with your weight. Rotate application sites daily and keep heating pads and other direct heat away from your patch because heat increases drug absorption. If you are an older adult with dementia-related psychosis, discuss the increased risk of death with your prescriber; this patch is not approved for that use.
What to do
- **Rotate sites:** Apply your new patch to a different area of clean, dry, intact skin each day.
- **Avoid heat:** Keep your patch away from heating pads, electric blankets, and hot tubs.
- **Prevent falls:** Stand up slowly and avoid driving until you know how the patch affects you.
- **Avoid alcohol:** Alcohol can make your side effects worse.
- **Keep monitoring appointments:** Have your weight, blood sugar, and cholesterol checked as your prescriber recommends.
- **Report movement changes:** Contact your prescriber promptly if you develop movements you cannot control.
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