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Short answer Living with deuruxolitinib: what to watch for Common questions Related questions SourcesThe most common side effects of deuruxolitinib (brand name Leqselvi) are headache, acne, upper respiratory infections, folliculitis, fatigue, and changes in hair texture.
Most of these are mild and show up in the first weeks as your body adjusts. Because deuruxolitinib is a JAK inhibitor, it also carries a boxed warning for serious infections, blood clots, major heart events, cancer, and death, which is why your clinician screens you for tuberculosis and hepatitis and rechecks blood counts, lipids, and liver tests during treatment. Your genetics matter here too: people who are CYP2C9 poor metabolizers, and people taking strong CYP2C9 inhibitors such as fluconazole, should not take this drug because levels build up too high. Report fever, cough that will not quit, shingles-type rash, or leg swelling and chest pain right away rather than waiting for your next visit.
Living with deuruxolitinib: what to watch for
Common questions
What are the side effects of Deuruxolitinib?
The most common side effects of deuruxolitinib are headache, acne, upper respiratory infections, folliculitis, fatigue, and changes in hair texture. Some people also notice weight gain, higher creatine kinase on labs, cold sores, urinary tract infections, back pain, or trouble sleeping. Like other JAK inhibitors, it has a boxed warning for serious infections, blood clots, heart attack and stroke, cancer, and death, so you need TB and hepatitis screening first and periodic blood work after. It is not used in CYP2C9 poor metabolizers or with strong CYP2C9 inhibitors. Call your clinician for fever, persistent cough, a painful rash, or leg swelling with chest pain or shortness of breath.