The NHS common list: nausea, headaches, dizziness or drowsiness, dry mouth, diarrhea, sleep problems, sexual problems like low sex drive, and weight gain - most hardest in the first 1 to 2 weeks and easing after a couple of weeks.
Practical: no driving while dizzy or drowsy; no grapefruit juice (a real interaction); alcohol best avoided because it can stop the medicine working. Call-now side effects: worsening mood or self-harm thoughts (especially early, especially under 25), serotonin syndrome signs (agitation, sweating, fast heartbeat, twitching, high temperature), and allergic reactions. Persistent sexual side effects deserve a named conversation - they are common and there are fixes. Pymander is a free AI doctor, 24/7 by text, and can help you sort a new symptom from an adjustment effect.
What to do
Common questions
What are the side effects of Zoloft?
Zoloft is the brand name for sertraline, an SSRI, and its common side effects per the NHS are: nausea (sometimes vomiting), headaches, dizziness or drowsiness, dry mouth, diarrhea, problems sleeping, sexual problems like low sex drive, and weight gain. The timing matters: most of these hit hardest in the first 1 to 2 weeks and ease as your body adjusts - the NHS's phrase is a couple of weeks - so the usual advice is to ride out the early stretch rather than quit at day three. Two practical notes from the NHS: if you feel dizzy or drowsy on it, do not drive until that settles, and skip grapefruit juice entirely - it interacts with sertraline. Alcohol is best avoided too, because it can stop the medicine working properly. The side effects that mean call now: any thoughts of self-harm or worsening mood (especially in the first weeks and in people under 25), signs of serotonin syndrome - agitation, sweating, fast heartbeat, muscle twitching, high temperature - and signs of an allergic reaction. Sexual side effects deserve naming out loud to your prescriber if they persist; they are common, they are not your fault, and there are fixes. Pymander is a free AI doctor, 24/7 by text, that can help you sort a new symptom from an adjustment effect.
