What cant you take while pregnant?

Last updated September 3, 2026.

The avoid list: NSAIDs (ibuprofen, naproxen, regular aspirin) after 20 weeks, isotretinoin, ACE inhibitors and ARBs, valproate, warfarin, weight-loss drugs including GLP-1s, and high-dose vitamin A. Acetaminophen is the default pain reliever. The reasoning: NSAIDs after 20 weeks risk fetal kidney problems and early closure of a heart vessel, per the FDA; isotretinoin causes severe birth defects, which is why the iPLEDGE prevention program exists. The caution middle: pseudoephedrine (first-trimester avoid), Pepto-Bismol and other salicylates, herbal supplements, and caffeine over about 200 mg daily. Two meta-rules beat memorizing: check anything new with your OB, pharmacist, or MotherToBaby first, and never stop a necessary medication on your own, because untreated depression, asthma, or seizures often outrisk the drug; the right move is adjusting together with your prescriber. Planning ahead is the real win: a preconception visit lets you swap problem medications before they matter.

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