What causes chronic hives?

Last updated September 3, 2026.

Chronic hives (welts recurring past 6 weeks) are usually chronic spontaneous urticaria - no external cause is found in most cases, and it is NOT typically an allergy. Worth checking: physical triggers (pressure, cold, heat, sweat, sun), medications (NSAIDs worsen hives), infections, and thyroid or autoimmune conditions - a couple of blood tests cover the medical leads. Daily non-drowsy antihistamines, often at clinician-guided higher doses, control most cases; stubborn ones have specialist options like omalizumab. Meanwhile avoid the aggravators: NSAIDs, alcohol, heat, tight clothing. Hives plus lip, tongue, or throat swelling or breathing difficulty is anaphylaxis - emergency care. Pymander is a free AI doctor, 24/7 by text, and can help you document your pattern.

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