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What happens if you miss a dose of Agalsidase beta Injection?

Updated Sep 7, 20262 min readAnswer
On this pageShort answer What to do about a missed infusion Common questions Related questions Sources
Short answer

**If you miss a dose of agalsidase beta injection, contact your infusion center or specialist right away to reschedule; the dose is usually given as soon as it can be arranged rather than skipped.**

Agalsidase beta is given as an intravenous infusion about every two weeks in a clinic, hospital, or at home with a nurse, so a missed dose is really a missed appointment. Your care team will usually rebook the infusion within a few days instead of waiting for the next scheduled one, and they will not double the amount to make up for lost time. If you take premedication such as an antihistamine or acetaminophen before infusions, keep taking it as directed for the rescheduled visit. A gap of several weeks is worth a call to your metabolic or genetics specialist, who may want to review your symptoms and lab work. Booking the next infusion before you leave each visit, plus a calendar reminder, keeps the every-two-week rhythm steady.

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What to do about a missed infusion

1Call the same day:Let your infusion center know as soon as you realize you will miss a visit so they can offer the next open slot.
2Skip the catch-up dose:Never ask for a larger or extra infusion to make up for a missed one; the schedule resumes at the usual dose.
3Keep premedication as directed:If you normally take an antihistamine or acetaminophen before infusions, follow the same plan for the rescheduled visit.
4Book before you leave:Schedule the next infusion at the end of each visit and set a phone reminder two days ahead.
5Plan travel early:Tell your team weeks in advance about trips so they can shift a date or arrange infusion at another site.
6Report returning symptoms:Tell your metabolic or genetics specialist if pain, stomach problems, or fatigue increase after a long gap.

Common questions

What happens if you miss a dose of Agalsidase beta Injection?

Agalsidase beta (Fabrazyme) is an enzyme replacement therapy given by IV infusion, usually once every two weeks. You do not give it to yourself, so a missed dose almost always means a canceled or delayed appointment. Call your infusion center or specialist as soon as you know you will miss it, and they will fit you in as soon as possible. Do not try to make up the gap with a larger dose. When infusions stop for a long stretch, the fatty substance the enzyme clears can build up again and symptoms such as pain in the hands and feet, stomach upset, or fatigue may return. Ask your specialist how to handle repeated missed visits, travel, or a change in infusion site.

About this page. Written and maintained by the Pymander Health team. Last updated September 7, 2026.

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