What medications lower potassium?

Last updated September 3, 2026.

Diuretics are the main drug cause of low potassium, per MedlinePlus, with high-dose steroids, laxative overuse, and vomiting or diarrhea behind them. Potassium runs the heart's electrical system, so big drops cause weakness, cramps, and rhythm problems, which is why diuretic users get regular blood tests, and why options include potassium-sparing diuretic forms or prescribed supplements. Do not self-start potassium, since too much is as dangerous as too little; learn the weakness-cramps-palpitations cluster; and report vomiting or diarrhea promptly on these drugs, because a stomach bug can tip a borderline level fast.

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