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What medications raise blood pressure?

Updated Sep 3, 20261 min readAnswer
On this pageShort answer What to do Common questions Related questions Sources
Short answer

The AHA flags decongestants like pseudoephedrine and phenylephrine and NSAIDs like ibuprofen as blood pressure raisers, advising people with uncontrolled hypertension or heart disease to avoid oral decongestants.

Steroids, ADHD stimulants, some SNRI antidepressants, and combined birth control pills also raise readings. Practical moves: check cold-and-flu combo labels and ask the pharmacist for decongestant-free versions, mention daily NSAID use at blood pressure checks, and bring the start-date timeline if readings crept up after a new medicine. Never stop a prescribed drug over this list; monitoring or substitution is the answer.

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What to do

1Check cold-medicine labelsfor decongestants and NSAIDs.
2Ask the pharmacist for decongestant-free alternatives.
3Mention daily NSAID use at BP checks.
4Track readings after new medicines;bring the timeline in.

Common questions

What medications raise blood pressure?

Some everyday medicines push blood pressure up, and the American Heart Association names the two hiding in your cold medicine: decongestants like pseudoephedrine or phenylephrine, which constrict blood vessels to clear your nose and constrict the rest of you along with it, and NSAIDs like ibuprofen and naproxen, which appear in many cold and flu combos. The AHA's guidance is direct: people with uncontrolled high blood pressure or heart disease should avoid oral decongestants, and both decongestants and NSAIDs were listed as medications that could increase blood pressure in national hypertension guidelines. The wider prescription list: corticosteroids, stimulants for ADHD, some antidepressants, especially SNRIs, certain migraine and immunosuppressant drugs, and combined birth control pills in some women. What to do with this: if you have hypertension, check combo cold-and-flu labels before buying, and ask the pharmacist for a decongestant-free alternative, which exists for most symptoms; if you take NSAIDs daily for pain, mention it at your blood pressure checks rather than assuming it is irrelevant; do not stop a prescribed drug because of this list, since the answer is usually monitoring or substitution; and if your readings crept up after a new medicine, bring the start-date timeline to your appointment, because that pattern is diagnostic. Home monitoring during a new drug's first weeks turns guessing into data.

About this page. Written and maintained by the Pymander Health team. Last updated September 3, 2026.

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