What medications raise blood pressure?

Last updated September 3, 2026.

The AHA flags decongestants like pseudoephedrine and phenylephrine and NSAIDs like ibuprofen as blood pressure raisers, advising people with uncontrolled hypertension or heart disease to avoid oral decongestants. Steroids, ADHD stimulants, some SNRI antidepressants, and combined birth control pills also raise readings. Practical moves: check cold-and-flu combo labels and ask the pharmacist for decongestant-free versions, mention daily NSAID use at blood pressure checks, and bring the start-date timeline if readings crept up after a new medicine. Never stop a prescribed drug over this list; monitoring or substitution is the answer.

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