What STD symptoms should I never ignore?

Last updated September 3, 2026.

Never ignore genital sores or blisters, unusual discharge, burning urination, pelvic or testicular pain, rectal symptoms after anal sex, or a palms-and-soles rash. But the bigger rule: most STIs are silent, so test after any risk, symptoms or not. Chlamydia is asymptomatic in most women; herpes and HPV spread from people who feel fine. So the actionable rule is testing after new partners, unprotected sex, a partner's diagnosis, or any symptom above, plus routine screening with multiple partners. Most bacterial STIs (chlamydia, gonorrhea, syphilis, trichomoniasis) are curable with antibiotics; HIV and herpes are manageable. Ignoring costs more than testing, especially for fertility: untreated chlamydia and gonorrhea cause pelvic inflammatory disease and infertility in women. One masquerader: sudden severe testicular pain can be torsion, not infection, and is a same-hour emergency. Pregnant women should treat any symptom as urgent, since several STIs transmit to the baby.

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