Why do I get canker sores when stressed?

Last updated September 3, 2026.

Because canker sores are immune-mediated and stress is a recognized trigger: in genetically susceptible people (up to 46% have family history), a T-cell-driven attack on the mouth's soft lining produces the ulcer - and StatPearls lists stress alongside trauma and iron, folate, B12, and zinc deficiency as linked factors. The mechanism is not fully mapped, but the stress-sore pattern is consistent enough to be clinical consensus. Pymander's escalation routing is built and tested specifically for this class of decision; see the safety architecture working paper.

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