On this page
In short What are the symptoms of ALS (Lou Gehrig's disease)? How does a doctor diagnose ALS (Lou Gehrig's disease)? How is ALS (Lou Gehrig's disease) treated? When is ALS (Lou Gehrig's disease) an emergency? What a Pymander AI doctor consult looks like Related questions Common questions SourcesALS, or amyotrophic lateral sclerosis, is a progressive disease that damages the nerve cells controlling voluntary muscle movement.
It gradually weakens the muscles used for moving, speaking, swallowing, and eventually breathing, while thinking and senses usually stay intact. Treatment focuses on slowing progression with medication, managing symptoms with a multidisciplinary team, and supporting breathing and nutrition as the disease advances. The urgency changes sharply when swallowing or breathing becomes difficult, since those problems can turn into emergencies quickly.
What are the symptoms of ALS (Lou Gehrig's disease)?
- Muscle weakness in a hand, arm, leg, or foot that gets worse over time
- Muscle twitching (fasciculations) and cramping, especially in the arms and legs
- Slurred or slow speech that gradually worsens
- Difficulty swallowing or chewing food
- Muscle stiffness (spasticity) and exaggerated reflexes
- Unexplained weight loss from muscle wasting
- Shortness of breath or trouble breathing when lying down
Symptoms that stay confined to one area for years, come and go, or are accompanied by numbness or vision changes point away from ALS and toward other neurological conditions.
How does a doctor diagnose ALS (Lou Gehrig's disease)?
ALS is usually suspected after months of progressively worsening weakness that a person first noticed as tripping, dropping objects, or slurring words, and it's confirmed by ruling out other causes rather than by a single test. A neurologist takes a detailed history of when weakness started and how it has spread, then checks reflexes, muscle strength, and looks for both upper and lower motor neuron signs on exam. Electromyography (EMG) and nerve conduction studies show the pattern of nerve damage, while blood tests, MRI of the brain and spine, and sometimes genetic testing are used to exclude look-alike conditions such as a pinched nerve, thyroid disease, or myasthenia gravis. Because there's no single confirmatory test, diagnosis often takes months and may involve a second opinion from an ALS specialty clinic.
How is ALS (Lou Gehrig's disease) treated?
Riluzole: This oral medication, taken twice daily, is the first-line disease-modifying drug for ALS and can modestly extend survival by reducing glutamate-related nerve damage.
Edaravone: Given as an IV infusion or oral suspension in monthly cycles, this antioxidant medication can slow the decline in physical function for some people with early-stage ALS.
Symptom management: Muscle relaxants such as baclofen or tizanidine treat spasticity, and other medications control cramping, excess saliva, and involuntary crying or laughing (pseudobulbar affect).
Breathing support: Noninvasive ventilation (BiPAP) is started once breathing tests decline, and it both eases symptoms and can extend survival.
Multidisciplinary care: Physical, occupational, and speech therapy, along with nutrition support and assistive devices, are coordinated through an ALS clinic to maintain function and quality of life as the disease progresses.
When is ALS (Lou Gehrig's disease) an emergency?
In an emergency, call 911Call 911 or go to the ER if someone with ALS has sudden severe shortness of breath, is choking and can't clear their airway, turns blue around the lips, or becomes confused or extremely drowsy, since these can signal respiratory failure or aspiration. Go to urgent care or call your ALS clinic the same day for new swallowing trouble with coughing during meals, a fall with injury, or weakness that worsens rapidly over days. Slow, gradual changes in strength or speech should be discussed with your neurology or ALS clinic team rather than treated as an emergency.
How our AI doctor decides when to send you to care ›What a Pymander AI doctor consult looks like
- How to treat hand foot and mouth disease
- Is ed a sign of heart disease
- Is fifth disease dangerous in pregnancy
Common questions
Is ALS the same as Lou Gehrig's disease?
Yes, ALS and Lou Gehrig's disease are the same condition. The name comes from the New York Yankees baseball player Lou Gehrig, who was diagnosed with it in 1939 and helped bring public attention to the disease.
What causes ALS?
Most cases have no known cause and are called sporadic ALS. About 5 to 10 percent are inherited, linked to gene mutations such as C9orf72 or SOD1, and genetic testing and counseling are available for people with a family history of the disease.
How fast does ALS progress?
Progression varies widely from person to person. Weakness typically spreads from where it started to nearby muscle groups over months, and while many people live a few years from diagnosis, some live much longer, especially with early treatment and breathing support.
Can ALS be cured?
There is currently no cure for ALS. Treatment focuses on slowing progression with medication, managing symptoms, and supporting breathing and nutrition to maintain function and quality of life for as long as possible.
What's the difference between ALS and MS?
ALS damages motor neurons and causes muscle weakness without affecting sensation, vision, or bladder control. Multiple sclerosis damages the protective coating of nerves in the brain and spinal cord and often causes numbness, vision problems, and bladder issues in addition to weakness, with a relapsing-remitting course that ALS does not have.
Does ALS affect thinking or memory?
Most people with ALS keep normal thinking and memory throughout the illness. A minority develop a related condition called frontotemporal dementia, which can affect judgment, behavior, or language, and your care team will typically screen for this overlap.