Methotrexate cost without insurance

Methotrexate price by strength

A 30 count is 30 units of the product (pills, capsules or the pack size Cost Plus lists), not a promise of 30 days. These are Cost Plus Drugs’ own cash prices, including their pharmacy fee. Shipping is added at their checkout. Pymander adds no fee or markup. Prices checked October 11, 2026 and can change.

Of the 10 medications in the Bones & joints group with a 30 count price in our catalog, Methotrexate costs less than 5 of the others. The middle price for that group is $7.93.

What Methotrexate is

A medicine that calms the immune system to slow joint damage in arthritis and clear psoriasis. At these doses it’s taken only once a week.

What it’s for

Rheumatoid arthritis, psoriatic arthritis and severe psoriasis.

How it’s taken

ONCE A WEEK, on the same day each week, not daily. Taking it every day by mistake has caused deaths. A folic acid pill is usually added to cut side effects.

Good to know

It carries a boxed warning: it can cause serious liver, lung, blood count and bowel problems, so regular blood tests are needed. It causes birth defects and miscarriage, and must be stopped before trying to conceive (for both partners). Mouth sores, fever, unusual bruising, or a new cough or shortness of breath need care right away. Avoid alcohol.

The plain-language description on this page was written from public medical sources and has not been reviewed by a clinician. Use it to get oriented, then check with your own clinician or pharmacist.

Who looks up Methotrexate

People search for Methotrexate when they are dealing with rheumatoid arthritis, psoriasis, psoriatic arthritis, juvenile arthritis. Methotrexate is a prescription medicine, so a licensed clinician has to decide it is right for you before a pharmacy can fill it.

For more on what it treats and how it is taken, see Methotrexate: what it treats, how to take it.

Where to get Methotrexate

Only Cost Plus Drugs publishes a machine-readable price list, so it is the only price we quote. For the others we link to their pages and do not guess a number.

How Pymander fits

Pymander is an AI-native, cash-pay healthcare system. This catalog lists prices from outside sources so you can compare before you pay, and Pymander does not sell Methotrexate or add a fee on top. You can text our free AI doctor with questions about a symptom or a medication, and bring the care note to the clinician who decides your treatment.