Acoltremon: dry eye treatment, how to use it, side effects
Last updated September 6, 2026.
**Acoltremon is a prescription eye drop for dry eye disease in the TRPM8 receptor agonist class.** It stimulates receptors involved in tear production, although its exact action in dry eye disease is unknown. Keep the vial tip from touching your eye or any surface to prevent contamination and injury.
What does it treat?
Sold as Tryptyr, acoltremon treats the signs and symptoms of dry eye disease. You may have burning, grittiness, or dryness when tears do not adequately moisten your eyes; a clinician checks your symptoms and eye surface before choosing treatment.
How do you take it?
The adult dose of 0.003% solution is one drop in each eye twice daily, approximately 12 hours apart: two drops per eye daily. Do not use extra doses. Wash your hands, use one single-dose vial for both eyes, and discard it immediately afterward. Remove contacts first and wait 15 minutes before reinserting them. Separate other eye drops by at least 5 minutes. Meals do not affect dosing. Skip a missed dose and resume at the next scheduled time. Stop and call your doctor for persistent pain, swelling, or eye injury.
Side effects to know
- Common: You may feel irritation, burning, or stinging when you put the drops in.
- Serious: Stop using the drops and get prompt medical help for eye or eyelid swelling, significant redness, persistent pain, or an eye injury. Call 911 for trouble breathing or swelling of your tongue or throat.
Who should not take it?
The FDA label lists no formal contraindications, but discuss any previous allergy to the ingredients before use. Tell your doctor about other medicines, eye conditions, and recent eye procedures. Safety and effectiveness in children are not established. Pregnancy studies in humans are inadequate; exposure through the bloodstream is negligible. Breast milk and infant effects are unknown, so discuss treatment while breastfeeding. The label specifies no alcohol restriction.
When is it an emergency?
For extra doses or accidental swallowing, call Poison Control at 1-800-222-1222; no specific overdose symptom pattern is established. Call 911 for collapse or breathing trouble, including a possible severe allergic reaction. Sudden vision loss or severe eye pain needs immediate emergency eye care.
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Common questions
What is the maximum daily dose?
Use one drop per eye twice daily, about 12 hours apart. That totals two drops per eye each day. Skip missed doses instead of doubling up.
Can I drink alcohol while using it?
The FDA label gives no specific alcohol restriction. It does not establish an alcohol interaction. Ask your pharmacist whether your other medicines require avoiding alcohol.
Can I use it during pregnancy or breastfeeding?
Discuss it with your prescriber first. Human pregnancy studies are inadequate, although bloodstream exposure is negligible. There are no data on breast milk levels or effects on your nursing baby. Your clinician weighs your treatment need and breastfeeding benefits.
Do I need to use the drops with food?
No meal timing is required. You can continue your normal diet. Use the drops at consistent morning and evening times.
What are the signs of an overdose?
The label does not identify specific overdose signs. If you use too much or swallow the solution, call Poison Control at 1-800-222-1222 without waiting for symptoms. Call 911 for collapse or breathing trouble.
Can I use other eye drops or contact lenses?
You can use other prescribed eye drops, spaced at least 5 minutes apart. Tell your clinician about every eye product you use. Remove contact lenses before dosing and wait 15 minutes before replacing them.