Acoramidis: what it treats, how to take it, side effects
Last updated September 6, 2026.
**Acoramidis, sold as Attruby, is a prescription transthyretin stabilizer used to treat a specific type of heart muscle disease.** It helps keep transthyretin proteins together so they are less likely to form harmful deposits. Have your prescriber check every medicine and supplement you take because interactions can reduce treatment effectiveness or increase other medicines' effects.
What does it treat?
You may receive acoramidis for confirmed transthyretin amyloid cardiomyopathy, called ATTR-CM, including inherited and wild-type forms. Protein deposits stiffen your heart and can cause breathlessness, fatigue, and leg swelling. Treatment reduces the risk of cardiovascular death and hospitalization; symptoms alone do not establish this diagnosis.
How do you take it?
Take two 356 mg tablets by mouth twice daily, totaling 712 mg per dose and 1,424 mg daily. Do not exceed that prescribed daily amount. Take with or without food and swallow whole without cutting, crushing, or chewing. Take a missed dose when remembered unless your next dose is almost due; then skip it. Never double up. Stop and get immediate help for signs of a severe allergic reaction; call your doctor for persistent diarrhea or stomach pain.
Side effects to know
- Common: You may develop diarrhea or upper stomach pain, usually mild.
- Serious: Stop taking acoramidis and get emergency help for throat swelling, trouble breathing, or hives with faintness, which suggest a severe allergic reaction to a medicine. These are general emergency precautions, not an established acoramidis adverse reaction listed in its label.
Who should not take it?
The FDA label lists no formal contraindications, but discuss any previous allergy to acoramidis or its ingredients before taking it. Tell your doctor about kidney problems, pregnancy, breastfeeding, and all medicines. Avoid combinations with UGT inducers or strong CYP3A inducers; some medicines processed by CYP2C9 need closer monitoring. Pregnancy risks and effects on breastfed babies are unknown. The label gives no specific alcohol restriction; follow your cardiologist's advice.
When is it an emergency?
Acoramidis overdose symptoms are not established. For an extra dose or suspected overdose, call Poison Control at 1-800-222-1222 immediately, even without symptoms. Call 911 for collapse, breathing trouble, a seizure, or inability to wake up. Chest pain or severe breathlessness at rest also requires emergency care because of your underlying heart condition.
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Common questions
What is the maximum daily dose?
Your labeled dose is 712 mg twice daily. That equals four 356 mg tablets, or 1,424 mg daily. Do not take extra tablets for worsening symptoms.
Can I drink alcohol?
The FDA label does not specify an alcohol limit. That does not establish that drinking is safe for your heart condition. Ask your cardiologist whether you should avoid alcohol.
Can I take it during pregnancy or breastfeeding?
Human pregnancy data are insufficient to determine risk. Whether acoramidis enters breast milk is unknown. Contact your prescriber promptly if you become pregnant, and discuss feeding plans before breastfeeding.
Do I need food with each dose?
You can take it with or without food. Use roughly the same times each day. Swallow tablets whole; ask your pharmacist for help if swallowing is difficult.
What symptoms mean I took too much?
There is no established overdose symptom pattern. Call Poison Control at 1-800-222-1222 without waiting for symptoms. Call 911 for collapse or breathing trouble.
Which interactions and blood test changes matter?
Do not start St. John's wort without checking with your prescriber. Acoramidis can increase exposure to medicines processed by CYP2C9, requiring closer monitoring. It can also raise creatinine and lower estimated kidney filtration early in treatment. Your clinician should interpret these changes alongside your symptoms and other results.