Agalsidase beta: what it treats, dosing, side effects
Last updated September 7, 2026.
**Agalsidase beta injection is an enzyme replacement therapy for Fabry disease.** It replaces an enzyme your body needs to break down certain fatty substances. Severe allergic reactions can happen even after years of treatment, so your infusions require medical supervision.
What does it treat?
You may receive agalsidase beta, sold as Fabrazyme, for confirmed Fabry disease if you are age 2 or older. This inherited disease causes fatty material to accumulate and damage nerves, kidneys, and the heart.
How do you take it?
A clinician mixes powder from 5 mg or 35 mg vials and gives it into your vein. The labeled adult dose is 1 mg/kg every 2 weeks; there is no daily dosing ceiling because this is not daily treatment. Infusions usually take at least 90 minutes and may take longer. Eat normally unless instructed otherwise. Call your infusion team promptly to reschedule a missed appointment. Report symptoms during treatment immediately; severe reactions require stopping the infusion and emergency treatment.
Side effects to know
- Common: You may experience chills, fever, headache, dizziness, fatigue, cough, or rash; report symptoms during your infusion immediately.
- Serious: Throat swelling, wheezing, fainting, or chest pain can signal a severe reaction requiring the infusion to stop and emergency treatment. Reactions can occur during treatment or within 24 hours afterward.
Who should not take it?
Discuss previous infusion reactions, allergies, and heart or kidney problems before treatment. The label lists no absolute contraindications, but restarting after a severe reaction requires specialist assessment. Review all medicines and supplements with your team. Pregnancy data have not identified a drug-associated risk; small amounts enter breast milk, with infant effects unknown. Discuss pregnancy, breastfeeding, and alcohol use before your next infusion.
When is it an emergency?
Call 911 for collapse, breathing trouble, throat swelling, or severe chest pain. For a suspected overdose, alert your infusion team and call Poison Control at 1-800-222-1222 immediately, even without symptoms. No specific overdose symptom pattern is established.
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Common questions
What is the maximum dose?
Your labeled dose is 1 mg/kg every 2 weeks. There is no separate daily maximum. Your infusion team calculates your dose from your weight.
Can I drink alcohol?
The label gives no specific alcohol restriction. Ask your team about your other medicines and organ health. Avoid alcohol with sedating infusion premedication.
Can I receive it during pregnancy or breastfeeding?
Tell your specialist before your next infusion. Available pregnancy reports have not identified increased drug-related risks. Small amounts reach breast milk, but effects on your baby remain unknown.
Should I eat before an infusion?
You can follow your normal diet. The infusion does not require fasting. Follow any separate instructions for your other conditions.
What are overdose signs?
There is no established symptom checklist for overdose. Call Poison Control at 1-800-222-1222 for a suspected dosing error. Call 911 for collapse or breathing trouble.
Does it interact with other medicines?
The FDA label lists no specific drug interactions. Give your team your complete medication and supplement list. Confirm which premedications you should take before each infusion.