Oriahnn: what it treats, how to take it, side effects
Last updated September 7, 2026.
**Oriahnn is a prescription combination of a GnRH receptor antagonist, estrogen, and progestin for heavy menstrual bleeding from fibroids.** Elagolix lowers ovarian hormone production; added hormones help limit bone loss and protect your uterine lining. This medicine increases your risk of blood clots, stroke, and heart attack.
What does it treat?
You may receive Oriahnn for heavy periods caused by confirmed uterine fibroids before menopause. Your clinician checks the cause of bleeding before prescribing this combination package.
How do you take it?
Take one morning capsule containing elagolix 300 mg, estradiol 1 mg, and norethindrone acetate 0.5 mg, then one evening capsule containing elagolix 300 mg. Take each at a consistent time, with or without food. Your daily ceiling is one of each capsule: elagolix 600 mg, estradiol 1 mg, and norethindrone acetate 0.5 mg. Take a missed dose within 4 hours of its scheduled time; otherwise skip it. Never double up. Stop by 24 months because bone loss may persist. Stop and call your doctor if you become pregnant or develop jaundice.
Side effects to know
- Common: You may experience hot flashes, headaches, tiredness, or irregular bleeding.
- Serious: Stop taking it and get immediate help for chest pain, sudden breathlessness, one painful swollen leg, or sudden vision or speech changes. Yellow skin or eyes and suicidal thoughts also require immediate medical attention.
Who should not take it?
Do not take it during pregnancy, with osteoporosis, liver disease, unexplained uterine bleeding, hormone-sensitive cancer or high risk for it, ingredient allergy, or high clot risk, including previous clots, uncontrolled blood pressure, or smoking after age 35. Discuss migraines, heart disease, depression, planned surgery, and prolonged immobility first. Cyclosporine and gemfibrozil must not be combined with it. If breastfeeding, discuss treatment first: hormones enter milk and can reduce supply; elagolix's effects on nursing infants are unknown. Discuss alcohol use before drinking.
When is it an emergency?
Call 911 for collapse, breathing trouble, chest pain, sudden weakness or speech difficulty, or throat swelling suggesting anaphylaxis. For overdose, call Poison Control at 1-800-222-1222 immediately, even without symptoms; possible symptoms include vomiting, abdominal pain, breast tenderness, sleepiness, and vaginal bleeding. Get emergency help for suicidal thoughts with an immediate risk of acting on them.
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Common questions
What is the maximum daily dose?
Take only one morning capsule and one evening capsule daily. Do not substitute two morning capsules. Treatment must not exceed 24 months.
Can I drink alcohol?
The FDA label sets no specific alcohol allowance. Ask your clinician before drinking. Include how much and how often you drink in your medication review.
Can I become pregnant while taking it?
Yes; Oriahnn is not birth control. Use nonhormonal contraception during treatment and for 28 days afterward. Stop and contact your doctor if you become pregnant because early pregnancy loss is a risk.
Should I take it with food?
You can take either capsule with or without food. Keep consistent morning and evening times. Avoid grapefruit and grapefruit juice.
What should I do after an extra dose?
Call Poison Control at 1-800-222-1222 now. Do not wait for nausea, vomiting, sleepiness, or vaginal bleeding. Call 911 for collapse or breathing trouble.
Which medicines need an interaction check?
Tell your pharmacist about every prescription, supplement, and nonprescription medicine. Specifically flag cyclosporine, gemfibrozil, omeprazole, and St. John's wort. Have the review completed before adding or changing medicines.