Lanadelumab-flyo: uses, how to take it, side effects
Last updated September 7, 2026.
**Lanadelumab-flyo is a monoclonal antibody injection that prevents hereditary angioedema attacks.** It blocks plasma kallikrein, reducing substances that cause swelling. It does not treat an attack already underway, so keep your prescribed rescue treatment available.
What does it treat?
Sold as Takhzyro, it prevents hereditary angioedema attacks in people aged 2 years and older, including painful swelling of your limbs, face, intestines, or airway.
How do you take it?
You inject a prefilled syringe under your skin after training. The adult dose is 300 mg every 2 weeks; your prescriber may extend this to every 4 weeks after more than 6 months of good control. There is no daily dosing schedule or daily ceiling. Food does not affect dosing. Call your prescriber about missed doses; do not double up. Stop and get help for a serious allergic reaction.
Side effects to know
- Common: You may have injection site pain, redness, bruising, headache, cold symptoms, rash, dizziness, diarrhea, or muscle pain.
- Serious: Stop using it and get immediate help for hives with swelling, chest tightness, fainting, or difficulty swallowing or breathing.
Who should not take it?
Discuss previous drug allergies, all medicines, pregnancy, and breastfeeding before treatment. Human pregnancy and breast milk data are unavailable. The label specifies no alcohol restriction.
When is it an emergency?
Call 911 for collapse, breathing trouble, or tongue or throat swelling, whether from an allergic reaction or HAE. Follow your prescribed rescue plan while awaiting help. Overdose symptoms are not established: call Poison Control at 1-800-222-1222 after an extra dose, even without symptoms.
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Common questions
What is the maximum adult dose?
The highest recommended regimen is 300 mg every 2 weeks. It is not a daily medicine. Do not add doses for breakthrough attacks.
Can I drink alcohol?
The label gives no alcohol restriction. That does not establish safety for every situation. Ask your clinician about your other medicines.
Can I use it during pregnancy or breastfeeding?
Human safety data are unavailable. The antibody can cross the placenta. Review treatment and breastfeeding benefits and risks with your prescriber.
Do I need to eat before injecting?
You do not need a meal. Continue your usual diet. Keep your prescribed injection schedule.
What does an overdose look like?
No specific symptom pattern is established. Do not wait for symptoms. Call Poison Control at 1-800-222-1222.
Does it interact with medicines or tests?
Dedicated interaction studies have not been conducted. Share your medication list. It can affect the aPTT clotting test, so tell laboratory staff.