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Is Amphotericin B Injection addictive?

Updated Sep 8, 20262 min readAnswer
On this pageShort answer Amphotericin B and dependence: what to know Common questions Related questions Sources
Short answer

No, amphotericin B injection is not addictive and is not a controlled substance.

It is an antifungal given through a vein to treat serious fungal infections, and it does not produce craving, a high, tolerance in the addiction sense, or withdrawal when it is stopped. Almost all doses are given by a nurse or clinician in a hospital or infusion center, so there is no take-home supply to misuse. What can feel intense during treatment is the infusion itself, with fever, chills, shaking, nausea, or headache in the first hours, and your team may premedicate to blunt that. The medicine also affects the kidneys and blood potassium, so expect regular lab checks and steady fluid intake. Ask your clinician before stopping early, since an unfinished course lets the infection come back.

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Amphotericin B and dependence: what to know

1Separate side effects from addiction:Chills, fever, and nausea after an infusion are drug reactions that fade, not signs of a habit forming.
2Report infusion reactions:Tell the nurse during the infusion if you get shaking chills, a racing heart, or trouble breathing, since the rate or premedication can be adjusted.
3Protect your kidneys:Drink fluids as directed, keep every lab appointment, and list all other medicines you take so your team can spot ones hard on the kidneys.
4Watch your potassium and magnesium:Mention new muscle cramps, weakness, or an irregular heartbeat, because this medicine can lower these minerals and you may need supplements.
5Finish the course:Fungal infections need the full treatment length, so ask before skipping or stopping doses even once you feel better.
6Ask about the formulation:Confirm which amphotericin B product you are getting, since conventional and lipid forms have different doses and cannot be swapped one for one.

Common questions

Is Amphotericin B Injection addictive?

No. Amphotericin B injection is an antifungal medicine, not a controlled substance, and it does not cause craving, euphoria, or withdrawal. It is infused through a vein by trained staff, usually in a hospital or infusion center, so there is no supply kept at home to misuse. What people notice during treatment is infusion reactions such as fever, chills, nausea, and headache, along with effects on the kidneys and potassium levels, which is why your team runs blood tests during the course. Those are side effects, not dependence. Complete the full course as prescribed, and call your clinician about new fever, much less urine, or muscle weakness.

About this page. Written and maintained by the Pymander Health team. Last updated September 8, 2026.

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