Is Amphotericin B Injection addictive?
Last updated September 8, 2026.
No, amphotericin B injection is not addictive and is not a controlled substance. It is an antifungal given through a vein to treat serious fungal infections, and it does not produce craving, a high, tolerance in the addiction sense, or withdrawal when it is stopped. Almost all doses are given by a nurse or clinician in a hospital or infusion center, so there is no take-home supply to misuse. What can feel intense during treatment is the infusion itself, with fever, chills, shaking, nausea, or headache in the first hours, and your team may premedicate to blunt that. The medicine also affects the kidneys and blood potassium, so expect regular lab checks and steady fluid intake. Ask your clinician before stopping early, since an unfinished course lets the infection come back.
What to do
- Separate side effects from addiction: Chills, fever, and nausea after an infusion are drug reactions that fade, not signs of a habit forming.
- Report infusion reactions: Tell the nurse during the infusion if you get shaking chills, a racing heart, or trouble breathing, since the rate or premedication can be adjusted.
- Protect your kidneys: Drink fluids as directed, keep every lab appointment, and list all other medicines you take so your team can spot ones hard on the kidneys.
- Watch your potassium and magnesium: Mention new muscle cramps, weakness, or an irregular heartbeat, because this medicine can lower these minerals and you may need supplements.
- Finish the course: Fungal infections need the full treatment length, so ask before skipping or stopping doses even once you feel better.
- Ask about the formulation: Confirm which amphotericin B product you are getting, since conventional and lipid forms have different doses and cannot be swapped one for one.
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