Is Amphotericin B Liposomal Injection addictive?
Last updated September 8, 2026.
No, amphotericin B liposomal injection is not addictive and is not a controlled substance. It is an antifungal given through a vein to treat serious fungal infections, and it does not act on the brain reward pathways that drive craving or drug seeking. Stopping at the end of your course does not cause withdrawal symptoms. What people often notice instead is an infusion reaction: fever, chills, shaking, headache, or nausea during or shortly after the drip, which your care team can ease by slowing the rate or giving medicine beforehand. Because each dose is given by a clinician in a hospital or infusion center, there is no take-home supply to misuse. Finishing every scheduled dose matters more here than with most drugs, since stopping early lets the infection return.
What to do
- Separate reaction from craving: Chills, fever, and body aches during the drip are an infusion reaction and settle after the dose, not a sign of dependence.
- Ask about premedication: If reactions keep happening, ask whether a slower infusion rate or medicine given beforehand would help.
- Finish the full course: Complete every scheduled infusion even once you feel better, because stopping early lets the fungal infection come back.
- Keep lab appointments: Your team checks kidney function, potassium, and magnesium during treatment, so do not skip blood draws.
- Report warning signs: Tell your clinician about much less urine than usual, severe muscle weakness, an irregular heartbeat, trouble breathing, or a rash.
- Share your full med list: Some drugs, including other medicines that affect the kidneys, need dose changes or extra monitoring alongside this one.
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