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Is Amphotericin B Liposomal Injection addictive?

Updated Sep 8, 20262 min readAnswer
On this pageShort answer Liposomal amphotericin B and dependence: what to know Common questions Related questions Sources
Short answer

No, amphotericin B liposomal injection is not addictive and is not a controlled substance.

It is an antifungal given through a vein to treat serious fungal infections, and it does not act on the brain reward pathways that drive craving or drug seeking. Stopping at the end of your course does not cause withdrawal symptoms. What people often notice instead is an infusion reaction: fever, chills, shaking, headache, or nausea during or shortly after the drip, which your care team can ease by slowing the rate or giving medicine beforehand. Because each dose is given by a clinician in a hospital or infusion center, there is no take-home supply to misuse. Finishing every scheduled dose matters more here than with most drugs, since stopping early lets the infection return.

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Liposomal amphotericin B and dependence: what to know

1Separate reaction from craving:Chills, fever, and body aches during the drip are an infusion reaction and settle after the dose, not a sign of dependence.
2Ask about premedication:If reactions keep happening, ask whether a slower infusion rate or medicine given beforehand would help.
3Finish the full course:Complete every scheduled infusion even once you feel better, because stopping early lets the fungal infection come back.
4Keep lab appointments:Your team checks kidney function, potassium, and magnesium during treatment, so do not skip blood draws.
5Report warning signs:Tell your clinician about much less urine than usual, severe muscle weakness, an irregular heartbeat, trouble breathing, or a rash.
6Share your full med list:Some drugs, including other medicines that affect the kidneys, need dose changes or extra monitoring alongside this one.

Common questions

Is Amphotericin B Liposomal Injection addictive?

No. Amphotericin B liposomal injection is an antifungal medicine, not a controlled substance. It does not act on the brain reward pathways involved in addiction, so it does not cause cravings, drug seeking, or withdrawal when your course ends. Each dose is infused into a vein by a clinician, usually in a hospital or infusion center, so there is no take-home supply to misuse. Fever, chills, shaking, or nausea during an infusion is an infusion reaction, not dependence, and your team can slow the rate or premedicate you. Call your clinician if you miss a dose, feel worse, or notice much less urine than usual.

About this page. Written and maintained by the Pymander Health team. Last updated September 8, 2026.

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