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Is Ceftolozane and Tazobactam Injection addictive?

Updated Sep 7, 20261 min readAnswer
On this pageShort answer Ceftolozane-tazobactam and dependence: what to know Common questions Related questions Sources
Short answer

**No, ceftolozane and tazobactam injection is not addictive.**

This antibiotic combination, sold as Zerbaxa, treats certain bacterial infections through an infusion into your vein. It does not cause cravings or withdrawal, and you do not need to taper it to prevent withdrawal. Your treatment length depends on your infection and response, so follow your prescribing clinician's instructions. Antibiotic resistance means bacteria become harder to treat; it does not mean your body is addicted.

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Ceftolozane-tazobactam and dependence: what to know

1**Follow your schedule:**Receive each dose as prescribed and ask your care team what to do if you miss an infusion.
2**Discuss treatment changes:**Ask your prescribing clinician before stopping early, even if you feel better.
3**Report ongoing symptoms:**Contact your clinician if your infection symptoms worsen or remain after treatment.
4**Report severe diarrhea:**Contact your clinician promptly for watery or bloody diarrhea during or after treatment.
5**Get emergency help:**Call 911 if you develop trouble breathing or swelling of your face, tongue, or throat.

Common questions

Is Ceftolozane and Tazobactam Injection addictive?

No, ceftolozane and tazobactam injection (Zerbaxa) is not addictive and does not cause cravings or withdrawal. You receive it through a vein to treat certain bacterial infections. Repeated doses are needed to treat the infection, not because your body becomes dependent on the medicine. Follow your prescribed schedule and ask your clinician before stopping early or changing doses. If symptoms persist or return after treatment, contact your clinician for reassessment. Nausea or diarrhea can be side effects, not signs of addiction.

About this page. Written and maintained by the Pymander Health team. Last updated September 7, 2026.

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