What causes ALS - resources?

Last updated September 7, 2026.

**Most ALS has no known cause, but inherited gene changes cause some cases.** ALS, or amyotrophic lateral sclerosis, damages nerve cells that control your voluntary muscles. Most people who develop ALS have no known family history of it. If ALS runs in your family, a clinician or genetic counselor can explain what that means for you. Record any persistent changes in your strength, walking, or speech and discuss them with your clinician. MedlinePlus and the CDC offer information you can use to prepare for that conversation.

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