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What is Abacavir used for?

Updated Sep 6, 20262 min readAnswer
On this pageShort answer Starting abacavir: what to know Common questions Related questions Sources
Short answer

Abacavir is an antiretroviral medicine used together with other HIV medicines to treat HIV-1 infection in adults and children.

It is a nucleoside reverse transcriptase inhibitor, so it blocks a step HIV uses to make copies of itself, and it is always combined with at least one other HIV medicine. Most people take it inside a single tablet, such as abacavir with lamivudine, or abacavir with dolutegravir and lamivudine. Everyone needs an HLA-B*5701 blood test before the first dose, because people who carry that gene should take a different medicine instead. Taking it at the same time every day keeps the virus suppressed, and a clinician should guide any change, pause, or restart.

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Starting abacavir: what to know

1Get the gene test first:Ask for the HLA-B*5701 blood test before your first dose, since a positive result means abacavir is not the right medicine for you.
2Take it on schedule:Use a daily alarm or pill box and take your dose at about the same time, with or without food.
3Keep the full regimen:Abacavir only works as part of a complete HIV regimen, so do not skip or stop the other medicines in it.
4Know the early warning signs:Contact your clinician right away if fever, rash, vomiting, stomach pain, cough, or shortness of breath start in the first weeks.
5Never restart on your own:If you stopped abacavir after any reaction, do not take it again unless a clinician confirms it is safe.
6Review interactions:Tell your clinician about every prescription, supplement, and your alcohol use, because some of these change abacavir levels.

Common questions

What is Abacavir used for?

Abacavir treats HIV-1 infection. It is a nucleoside reverse transcriptase inhibitor, which blocks an enzyme HIV needs to copy itself. It is always taken with other HIV medicines, often as one combination tablet such as abacavir with lamivudine, or abacavir with dolutegravir and lamivudine. Taken every day as prescribed, it helps lower the virus in your blood to undetectable levels and protects your immune system. It does not cure HIV, does not treat hepatitis B, and is not used for HIV prevention. Before your first dose you need a blood test for HLA-B*5701, because people who carry it need a different medicine.

About this page. Written and maintained by the Pymander Health team. Last updated September 6, 2026.

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