How it worksSafetyHealth libraryOur mission Sign in Start a free consult
Pymander
Free consult

What is Acyclovir Buccal used for?

Updated Sep 7, 20262 min readAnswer
On this pageShort answer Using the acyclovir buccal tablet Common questions Related questions Sources
Short answer

Acyclovir buccal is a single-dose antiviral tablet you press onto your upper gum to treat recurrent cold sores on the lip and face in adults with a healthy immune system.

It works best when you use it within one hour of the first tingling, itching, or burning and before a blister forms. One 50 mg tablet is the whole course: it sticks to the gum and releases acyclovir locally as it slowly dissolves, so there is no second dose for that outbreak. It shortens the episode but does not clear herpes simplex virus from your body or prevent future cold sores. It is not the right product for genital herpes, shingles, or chickenpox, which are treated with acyclovir taken by mouth or given by vein. If you get frequent outbreaks, have a weakened immune system, or the sore spreads toward your eye, talk with a clinician instead of self-treating.

What is Acyclovir Buccal used for? Ask our AI doctor - a straight answer in plain language, free, 24/7. Start a free consult Free · Private · 24/7
Find answers about acyclovir buccalStart a free AI doctor consult

Using the acyclovir buccal tablet

1Treat at the first sign:Apply the tablet within one hour of tingling or burning and before the blister breaks out, since later use gives little benefit.
2Place it on the right side:Press the rounded side of the tablet against the upper gum above an incisor on the same side of your mouth as the cold sore, and hold it for 30 seconds.
3Leave it in place:Do not chew, crush, suck, or swallow the tablet; eat soft foods, drink fluids normally, and skip chewing gum until it dissolves.
4Know it is one dose:A single tablet is the full treatment for that outbreak, so do not add a second one if it falls out after six hours.
5Match the form to the infection:Buccal acyclovir is only for cold sores; genital herpes, shingles, and chickenpox need acyclovir by mouth or by vein.
6Ask a clinician when:Get medical advice if sores last longer than two weeks, keep coming back often, spread near your eye, or you have a weakened immune system.

Common questions

What is Acyclovir Buccal used for?

Acyclovir buccal tablets treat recurrent cold sores (herpes labialis) on the lip and face in adults with a normal immune system. You place one 50 mg tablet on your upper gum, just above an incisor on the same side as your symptoms, within one hour of the first tingling, itching, or burning and before a blister appears. The tablet sticks in place and releases acyclovir locally as it dissolves over several hours, so you take only one dose per outbreak. It does not cure herpes simplex or stop outbreaks from returning, and it is not used for genital herpes, shingles, or chickenpox.

About this page. Written and maintained by the Pymander Health team. Last updated September 7, 2026.

Questions about this?Start a free consult