What is Amoxapine used for?
Last updated September 7, 2026.
**Amoxapine is a tricyclic antidepressant used to treat depression.** It is prescribed for major depressive disorder and sometimes for people who have not responded to newer antidepressants. Your clinician will adjust dose slowly and monitor for side effects such as drowsiness, dry mouth, blood pressure changes, and movement problems. Tell your clinician about other medicines and health conditions before you start. Do not stop it suddenly without medical advice.
What to do
- **Tell your clinician:** List all prescription, over the counter, and herbal medicines you take.
- **Ask about alternatives:** Discuss newer antidepressants if you are older or have heart conditions.
- **Start low:** Take the prescribed starting dose at the same time each day unless told otherwise.
- **Watch for side effects:** Report severe drowsiness, movement problems, or new suicidal thoughts right away.
- **Avoid mixing:** Do not combine with MAO inhibitors or certain sleep and cold medicines without advice.
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