What is PrEP and who should take it?
Last updated September 3, 2026.
PrEP is medicine - pills or shots - that prevents HIV before exposure, for adults and adolescents without HIV whose sex or injection life carries real risk, per the CDC. Taken as prescribed, it is highly effective. It fits people with an HIV-positive partner, inconsistent condom use with unknown-status partners, an STI diagnosis in the past 6 months, or shared injection equipment. Expect an HIV test before starting and regular testing while on it; the shot removes the daily-pill adherence question. PrEP covers HIV only - condoms still carry the other STIs.
What to do
- Check the fit. Positive partner, unknown-status partners, recent STI, or shared equipment.
- Choose pills or shots. Daily adherence versus periodic clinic visits.
- Keep the testing appointments. Regular HIV and kidney checks are part of the deal.
- Keep condoms for the rest. PrEP stops HIV; it does nothing for the other STIs.
Related questions
- What is PEP and how fast do I need it?
- Can an online doctor prescribe PEP?
- Can you have an STI without symptoms?
- What is the window period for HIV testing?