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In short Fluorouracil cream price by strength What Fluorouracil cream is Who looks up Fluorouracil cream Where to get Fluorouracil cream How Pymander fits Common questions SourcesFluorouracil cream costs from $16.50 for one fill (40 g tube) at Cost Plus Drugs, depending on strength. It is the generic of Efudex.
Fluorouracil cream is a prescription medicine, so a licensed clinician has to decide it is right for you before a pharmacy can fill it. Prices as of October 11, 2026; no insurance needed.
Fluorouracil cream price by strength
| Strength | Price per fill | Pack | Cost Plus Drugs |
|---|---|---|---|
| 5% | $16.50 | Tube of Cream, 40 g | View |
A 30 count is 30 units of the product (pills, capsules or the pack size Cost Plus lists), not a promise of 30 days. These are Cost Plus Drugs’ own cash prices, including their pharmacy fee. Shipping is added at their checkout. Pymander adds no fee or markup. Prices checked October 11, 2026 and can change.
Of the 71 medications in the Skin group priced per fill in our catalog, Fluorouracil cream costs less than 39 of the others. The middle price for that group is $17.32.
What Fluorouracil cream is
A chemotherapy cream that destroys abnormal, sun-damaged skin cells while leaving most normal skin alone.
What it’s for
Actinic keratoses (rough, scaly precancer spots from sun damage) and some very shallow skin cancers.
How it’s taken
Applied to the treated area once or twice a day for a set number of weeks, as directed.
Good to know
The skin gets very red, raw and crusty during treatment; that is expected. It must not be used in pregnancy. People who lack an enzyme called DPD can have severe reactions. Keep it away from pets, as swallowing it can kill them.
The plain-language description on this page was written from public medical sources and has not been reviewed by a clinician. Use it to get oriented, then check with your own clinician or pharmacist.
Who looks up Fluorouracil cream
People search for Fluorouracil cream when they are dealing with actinic keratosis, precancerous skin spots, sun damage, rough scaly spots, superficial basal cell carcinoma. Fluorouracil cream is a prescription medicine, so a licensed clinician has to decide it is right for you before a pharmacy can fill it.
For more on what it treats and how it is taken, see Fluorouracil cream: what it treats, how to take it.
Where to get Fluorouracil cream
| Where | Price we can show | Note | Link |
|---|---|---|---|
| Cost Plus Drugs Mail-order pharmacy | $16.50 and up | Price includes their pharmacy fee. Shipping is per order. | Open |
| GoodRx Discount coupon | See price on their site | Free coupon prices at local pharmacies. Prices vary by pharmacy and ZIP code. | Open |
| Amazon Pharmacy Mail-order pharmacy | See price on their site | Search for this medication to see Amazon’s price. Prime members can add RxPass, a flat monthly fee for a list of common generics. | Open |
Only Cost Plus Drugs publishes a machine-readable price list, so it is the only price we quote. For the others we link to their pages and do not guess a number.
How Pymander fits
Pymander is an AI-native, cash-pay healthcare system. This catalog lists prices from outside sources so you can compare before you pay, and Pymander does not sell Fluorouracil cream or add a fee on top. You can text our free AI doctor with questions about a symptom or a medication, and bring the care note to the clinician who decides your treatment.
Common questions
How much does Fluorouracil cream cost without insurance?
Fluorouracil cream costs from $16.50 for one fill (40 g tube) at Cost Plus Drugs, depending on strength (October 11, 2026). Insurance is not billed.
Do I need a prescription for Fluorouracil cream?
Fluorouracil cream is a prescription medicine, so a licensed clinician has to decide it is right for you before a pharmacy can fill it.
Is there a cheaper way to buy Fluorouracil cream?
Compare Cost Plus Drugs with a discount coupon such as GoodRx at a local pharmacy, since prices differ by pharmacy and ZIP code. Ask the pharmacy for its cash price in writing before you pay.
Does Pymander charge extra for Fluorouracil cream?
No. The prices on this page are the outside source’s own prices. Pymander adds no fee or markup.