Can I take vitamin C with Adderall?
Last updated September 3, 2026.
Yes, but high-dose vitamin C around the same time can make Adderall work less well. The FDA prescribing information for Adderall states that acidifying agents lower blood levels and efficacy of amphetamines, and vitamin C (ascorbic acid) is the classic gastrointestinal acidifier. The effect is about dose and timing, not total avoidance: fruit at breakfast is fine, while a 500 or 1000 mg supplement or a large glass of orange juice taken with your dose can cut absorption. MedlinePlus also lists antacids and other products that interact with amphetamine salts, so the window around your dose matters in both directions.
What to do
- Space supplements: take vitamin C supplements a few hours after your Adderall dose, not with it.
- Watch acidic drinks: large amounts of orange juice or other citrus at dose time can have the same effect.
- Keep food normal: everyday vitamin C from meals is not a concern.
- Do not self-adjust: if Adderall feels weaker, tell your prescriber instead of raising your own dose.
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